112 datasets

ZivaHub2027 · dataset

OBJECTIVES: This study aimed to evaluate the technical feasibility of routine distributional analyses of healthcare interventions in Australia, by adapting a Health Inequality Impact Calculator for Queensland. Building on methods established in a previous study in England, the calculator compares the magnitude of health inequality impact across interventions for different diseases. METHODS: The ca

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue

<p dir="ltr">M6BUP, a prodrug of buprenorphine was manufactured as aqueous nanosuspension and physiochemical properties characterized. </p>

Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Crystal structure

<p dir="ltr">Research investigating adult rat ultrasonic vocalizations as affect-related markers during withdrawal from chronic oral nicotine, looking into effects of partner familiarity.</p>

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue

<p dir="ltr">Schematic illustration of <a href="" target="_blank">M6BUP prodrug </a>promoiety synthesis and characterization</p>

ZivaHub + Deakin Research Online + DMU Figshare + HKU DataHub + Swinburne Figshare + DaYta Ya Rona + SUNScholarData + figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue

<p>Commonly used for delivering fluorescent or bioluminescent reporters to target genes, lentiviral vectors are an “easy-to-clone” vehicle to study up- and downregulation of gene expression induced by drug inhibitors, cytokine stimulants, chemicals, and environmental toxicants. To produce viral particles safely, several plasmid constructs are delivered to human embryonic kidney cells (HEK293-T), w

ZivaHub + Deakin Research Online + DMU Figshare + HKU DataHub + Swinburne Figshare + DaYta Ya Rona + SUNScholarData + figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue

<p>Commonly used for delivering fluorescent or bioluminescent reporters to target genes, lentiviral vectors are an “easy-to-clone” vehicle to study up- and downregulation of gene expression induced by drug inhibitors, cytokine stimulants, chemicals, and environmental toxicants. To produce viral particles safely, several plasmid constructs are delivered to human embryonic kidney cells (HEK293-T), w

ZivaHub + Deakin Research Online + DMU Figshare + HKU DataHub + Swinburne Figshare + DaYta Ya Rona + SUNScholarData + figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue

<p>Commonly used for delivering fluorescent or bioluminescent reporters to target genes, lentiviral vectors are an “easy-to-clone” vehicle to study up- and downregulation of gene expression induced by drug inhibitors, cytokine stimulants, chemicals, and environmental toxicants. To produce viral particles safely, several plasmid constructs are delivered to human embryonic kidney cells (HEK293-T), w

ZivaHub + Deakin Research Online + DMU Figshare + HKU DataHub + Swinburne Figshare + DaYta Ya Rona + SUNScholarData + figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue

<p>Commonly used for delivering fluorescent or bioluminescent reporters to target genes, lentiviral vectors are an “easy-to-clone” vehicle to study up- and downregulation of gene expression induced by drug inhibitors, cytokine stimulants, chemicals, and environmental toxicants. To produce viral particles safely, several plasmid constructs are delivered to human embryonic kidney cells (HEK293-T), w

ZivaHub + Deakin Research Online + DMU Figshare + HKU DataHub + Swinburne Figshare + DaYta Ya Rona + SUNScholarData + figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue

Graphical Abstract<p></p>

ZivaHub2026 · dataset

<p dir="ltr">Background: An explicit, easy-to-read dispensed label design should support users in following medication instructions accurately. Objective: To investigate the impact of user-centred labels (UCL) on medication users’ instruction comprehension compared with usual label formats. <br>Methods: A systematic search was conducted across relevant databases. The Preferred Reporting Items for

ZivaHub2026 · dataset

<p dir="ltr">Background: Although grounded theory (GT) is a valuable qualitative methodology, its application within pharmacy practice research remains unclear. Objectives: To map the diverse ways in which GT has been implemented in specific areas of pharmacy practice and to thematically synthesize the key findings. <br>Methods: Using the Preferred Reporting Items for Systematic Reviews and Meta-A

ZivaHub2026 · dataset

<p dir="ltr">Background: Silencing CD47, a “don’t eat me” signal on breast cancer cells, with small interfering RNA (siRNA), restores macrophage-mediated phagocytosis. Lipid nanoparticles (LNPs) deliver siRNA, but the stabilising PEG layer tends to trap them in endosomes (pH <6) (the PEGylation dilemma). We aim to develop acid-cleavable PEG-lipid LNP (PEGCL-LNP/siCD47) that will ‘shed’ in acidic e

ZivaHub + Deakin Research Online + DMU Figshare + HKU DataHub + Swinburne Figshare + DaYta Ya Rona + SUNScholarData + figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue

<p dir="ltr">Supplementary files for article "The Loughborough alcohol drinking questionnaire (LoAD-Q) for assessment of emotional, external, and restrained drinking behaviour"<br><br>Researching alcohol-related addictive behaviours typically utilises questionnaires which measure an individual’s level of alcohol use. However, these questionnaires typically either rely on a participant reporting th

ZivaHub2026 · dataset

<p>The synthetic triazolylpeptidyl penicillin derivative, named TAP7f, has been previously characterized as an effective antitumor agent in vitro and in vivo against B16-F0 melanoma cells. In this study, we investigated the anti-metastatic potential of this compound on highly metastatic murine B16-F10 and human A375 melanoma cells. We found that TAP7f inhibited cell adhesion, migration and invasio

ZivaHub2026 · dataset

<p>The synthetic triazolylpeptidyl penicillin derivative, named TAP7f, has been previously characterized as an effective antitumor agent in vitro and in vivo against B16-F0 melanoma cells. In this study, we investigated the anti-metastatic potential of this compound on highly metastatic murine B16-F10 and human A375 melanoma cells. We found that TAP7f inhibited cell adhesion, migration and invasio

ZivaHub + HKU DataHub + DaYta Ya Rona + figshare + Loughborough Research Repository + UP Research Data Repository2026 · Astronomical catalogue

<p>Di(2-ethylhexyl) phthalate (DEHP) is a widespread endocrine-disrupting plasticizer associated with metabolic disorders. To elucidate their mechanistic basis, we developed an Adverse Outcome Pathway Network (AOPN) informed by DEHP-induced perturbations, by integrating multi-omics data, systems biology modeling, and targeted literature evidence. Multi-omics data were generated in 3D human hepatic

ZivaHub2026 · dataset

<p dir="ltr">This is a preprint and has not been peer reviewed. This deposit includes the manuscript, Figures 1 and 2, and supplementary material.</p><p dir="ltr">Background: Incretin-based therapies provide benefits for type 2 diabetes and obesity, and their use is rapidly expanding. However, non-approved or inappropriate use is also increasing, sometimes without adequate medical supervision, rai

ZivaHub2026 · dataset

<p>The synthetic triazolylpeptidyl penicillin derivative, named TAP7f, has been previously characterized as an effective antitumor agent in vitro and in vivo against B16-F0 melanoma cells. In this study, we investigated the anti-metastatic potential of this compound on highly metastatic murine B16-F10 and human A375 melanoma cells. We found that TAP7f inhibited cell adhesion, migration and invasio

ZivaHub + HKU DataHub + DaYta Ya Rona + figshare + Loughborough Research Repository + UP Research Data Repository2026 · Astronomical catalogue

<p>Di(2-ethylhexyl) phthalate (DEHP) is a widespread endocrine-disrupting plasticizer associated with metabolic disorders. To elucidate their mechanistic basis, we developed an Adverse Outcome Pathway Network (AOPN) informed by DEHP-induced perturbations, by integrating multi-omics data, systems biology modeling, and targeted literature evidence. Multi-omics data were generated in 3D human hepatic

ZivaHub2026 · dataset

<p>The synthetic triazolylpeptidyl penicillin derivative, named TAP7f, has been previously characterized as an effective antitumor agent in vitro and in vivo against B16-F0 melanoma cells. In this study, we investigated the anti-metastatic potential of this compound on highly metastatic murine B16-F10 and human A375 melanoma cells. We found that TAP7f inhibited cell adhesion, migration and invasio

ZivaHub2026 · dataset

<p dir="ltr">Background: Tumour hypoxia remains a major obstacle to effective cancer treatment, contributing to therapeutic resistance and poor clinical outcomes. Localised tumour reoxygenation has the potential to improve the efficacy of conventional therapies; however, no clinically established oxygen delivery strategy currently exists. Oxygen-loaded microbubbles offer a promising platform for t

ZivaHub2026 · dataset

<p>The synthetic triazolylpeptidyl penicillin derivative, named TAP7f, has been previously characterized as an effective antitumor agent in vitro and in vivo against B16-F0 melanoma cells. In this study, we investigated the anti-metastatic potential of this compound on highly metastatic murine B16-F10 and human A375 melanoma cells. We found that TAP7f inhibited cell adhesion, migration and invasio

ZivaHub + HKU DataHub + figshare + Loughborough Research Repository + UP Research Data Repository2026 · Astronomical catalogue

<p dir="ltr">Raw data analyzed for the randomized, crossover study evaluating two active learning strategies, gamification versus Socratic learning, in the domain of medical pharmacology and therapeutics.<br><br>Updated file (Version 3): Added sheets for DIFI and DI calculation. 'Codesheet' has been updated accordingly.<br><br>Update (Version 4): Edited title.<br><br>Update (Version 5): Corrected

ZivaHub + HKU DataHub + DaYta Ya Rona + figshare + Loughborough Research Repository + UP Research Data Repository2026 · Astronomical catalogue

<p>Di(2-ethylhexyl) phthalate (DEHP) is a widespread endocrine-disrupting plasticizer associated with metabolic disorders. To elucidate their mechanistic basis, we developed an Adverse Outcome Pathway Network (AOPN) informed by DEHP-induced perturbations, by integrating multi-omics data, systems biology modeling, and targeted literature evidence. Multi-omics data were generated in 3D human hepatic

HKU DataHub + figshare + Loughborough Research Repository2026 · Astronomical catalogue

<p>Artificial intelligence (AI), particularly in the form of large language models (LLMs), offers promising support for toxicological risk assessment (TRA), which integrates multiple lines of evidence to support health-based conclusions, including those used in regulatory decision-making. Effective use of LLMs in TRA requires a clear understanding of their strengths and limitations, especially in