NCBI GEO2026 · Excel spreadsheet · 6 samples
Bulk RNA-seq of PD1+/- T cels from mouse hearts 7 days post MI…In order to deeply investigate the expression characteristics of PD1+ T cells in heart during myocardial infarction (MI), we firstly performed single-cell RNA sequencing (scRNA-seq)… …In order to deeply investigate the function of PD1+ T cells in heart during MI, we performed single-cell RNA sequencing (scRNA-seq) to detect the change T cells from anti-IgG and anti-PD1…
NCBI GEO2026 · Excel spreadsheet · 16 samples
CCR8 expression on regulatory T cells reveals trajectories of tissue adaptation and protects against myocardial infarction [bulk RNA-seq]…We employed single-cell RNA sequencing (scRNA-seq) in a mouse model of MI to gain a detailed analysis of heart and lymphoid Tregs, focusing on their developmental trajectories.… …the mediastinal lymph node (mLN) and heart after MI identified three Treg populations, one of which was mainly derived from the heart.…
NCBI GEO2026 · Excel spreadsheet · 12 samples
Cysteine and Glycine Rich Protein 3 (Csrp3) modulates cardiomyocyte mitotic cell cycle entry through Ring Finger Protein 5 (Rnf5)/p38 MAPK dependent pathway…In MADM mice, Csrp3 KD results in a significant increase in single coloured cells which indicates complete CM cell division confirming the role of Csrp3 in modulating mitosis in CMs… …Moreover, Rnf5 overexpression in human heart slices results in activation of CM cell cycle while Rnf5 KD in naturally proliferating neonatal P1 CM reduced cell cycle activity.…
NCBI GEO2026 · Excel spreadsheet · 6 samples
Valve organoids recapitulate human in vivo organogenesis and pathological processes…Heart valves maintain unidirectional blood flow, yet most understanding of their development and disease comes from animal models that do not fully capture human valve physiology.… …We have profiled the valve cells using single cell mRNA-sequencing at different developmental stages.…
NCBI GEO2026 · Excel spreadsheet · 468 samples
Cardiopedia-Ligand: a Ligand Stimulation Atlas for Cardiac Function and Transcriptional Response…receptors expressed in the human heart.… …We developed an automated high-throughput pipeline enabling individualized contractility measurements and single-organoid mRNA-sequencing.…