16,240 datasets

NCL Data2026 · dataset

<p>Results of DeSeq2 analysis of RNA-seq data for ∆rtt109 vs WT.</p>

NCL Data2026 · dataset

<div><p>A central challenge in downstream single-cell RNA sequencing (scRNA-seq) analysis is the high-dimensional, small-sample (HDSS) regime, often compounded by class imbalance from rare cell types. These factors hinder robust feature (gene) selection and cell clustering and limit the realism of samples generated by existing simulators. We introduce <i>GARAGE</i>, a <b>G</b>raph-<b>A</b>ttentive

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Single-cell RNA sequencing

Introduction<p>Avian heterophils naturally lack myeloperoxidase (MPO), making chicken a unique evolutionary model for investigating MPO-independent innate immune strategies. However, the molecular programs governing heterophil maturation and activation remain largely unexplored.</p>Methods<p>Using single-cell RNA sequencing in a RAG1-deficient chicken model, we mapped heterophil maturation during

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue

<p dir="ltr">This dataset provides the processed data supporting the manuscript"LCP modulates hepatic gluconeogenesis and gut microbiota in juvenileMicropterus salmoides (largemouth bass)" (submitted to the EgyptianJournal of Aquatic Research). It contains eight summary tablesextracted from the doctoral dissertation (Fan, UMS 2026) and, fromVersion 2, four full-resolution matrices generated direct

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Single-cell RNA sequencing

<p>Congenital melanocytic naevi (CMN) are usually associated with activating alterations in NRAS or BRAF, but some extensive lesions lack detectable canonical hotspot variants. We report a 9-year-old boy with a large craniofacial CMN involving the face, scalp, upper eyelid and bulbar conjunctiva, with deep extension, mechanical ptosis and secondary amblyopia. Histology showed benign dermal melanoc

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue

Introduction<p>Sexual dimorphism in avian skeletal muscle is established during embryogenesis, but the stage-resolved transcriptional programs governing this process in geese remain largely unexplored.</p>Methods<p>To construct a stage-specific transcriptional atlas of muscle satellite cells (SMSCs), we performed histological examination and RNA sequencing of PAX7⁺ SMSCs isolated from m

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Single-cell RNA sequencing

Background<p>High-risk neuroblastoma frequently relapses after intensive therapy, but the treatment-associated malignant-neuroblast programs that inform baseline tumor risk remain incompletely defined. We used longitudinal single-cell/single-nucleus RNA-seq data to identify post-treatment transcriptional changes in malignant neuroblasts and evaluated their prognostic relevance in diagnostic bulk R

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue

Introduction<p>Sexual dimorphism in avian skeletal muscle is established during embryogenesis, but the stage-resolved transcriptional programs governing this process in geese remain largely unexplored.</p>Methods<p>To construct a stage-specific transcriptional atlas of muscle satellite cells (SMSCs), we performed histological examination and RNA sequencing of PAX7⁺ SMSCs isolated from m

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue

Introduction<p>Sexual dimorphism in avian skeletal muscle is established during embryogenesis, but the stage-resolved transcriptional programs governing this process in geese remain largely unexplored.</p>Methods<p>To construct a stage-specific transcriptional atlas of muscle satellite cells (SMSCs), we performed histological examination and RNA sequencing of PAX7⁺ SMSCs isolated from m

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Single-cell RNA sequencing

Introduction<p>Avian heterophils naturally lack myeloperoxidase (MPO), making chicken a unique evolutionary model for investigating MPO-independent innate immune strategies. However, the molecular programs governing heterophil maturation and activation remain largely unexplored.</p>Methods<p>Using single-cell RNA sequencing in a RAG1-deficient chicken model, we mapped heterophil maturation during

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue

Background<p>The functional impairment of retinal microvascular cells is an early and central event in diabetic retinopathy (DR). Methylglyoxal (MGO), the most reactive precursor of advanced glycation end products (AGEs), has been implicated in vascular injury and neuro-retinal dysfunction. Its direct effects on retinal endothelial cells and underlying molecular mechanisms remain poorly understood

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue

Introduction<p>Sexual dimorphism in avian skeletal muscle is established during embryogenesis, but the stage-resolved transcriptional programs governing this process in geese remain largely unexplored.</p>Methods<p>To construct a stage-specific transcriptional atlas of muscle satellite cells (SMSCs), we performed histological examination and RNA sequencing of PAX7⁺ SMSCs isolated from m

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Single-cell RNA sequencing

Introduction<p>Avian heterophils naturally lack myeloperoxidase (MPO), making chicken a unique evolutionary model for investigating MPO-independent innate immune strategies. However, the molecular programs governing heterophil maturation and activation remain largely unexplored.</p>Methods<p>Using single-cell RNA sequencing in a RAG1-deficient chicken model, we mapped heterophil maturation during

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue

Objective<p>Pancreatic ductal adenocarcinoma (PDAC) exhibits profound molecular and metabolic heterogeneity associated with distinct phenotypic states. However, the contribution of transcription factor (TF)-driven regulatory programs to metabolic subtype stratification remains poorly understood. This study aims to determine whether TF-based classification can identify prognostically relevant glyco

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Single-cell RNA sequencing

Background<p>High-risk neuroblastoma frequently relapses after intensive therapy, but the treatment-associated malignant-neuroblast programs that inform baseline tumor risk remain incompletely defined. We used longitudinal single-cell/single-nucleus RNA-seq data to identify post-treatment transcriptional changes in malignant neuroblasts and evaluated their prognostic relevance in diagnostic bulk R

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue

Background<p>The functional impairment of retinal microvascular cells is an early and central event in diabetic retinopathy (DR). Methylglyoxal (MGO), the most reactive precursor of advanced glycation end products (AGEs), has been implicated in vascular injury and neuro-retinal dysfunction. Its direct effects on retinal endothelial cells and underlying molecular mechanisms remain poorly understood

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Single-cell RNA sequencing

<p dir="ltr">Seurat object (Filtered, processed scRNA-seq data) from Sakimoto et al, BJC Reports, 2024 (https://doi.org/10.1038/s44276-024-00112-3).</p>

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue

Background<p>The functional impairment of retinal microvascular cells is an early and central event in diabetic retinopathy (DR). Methylglyoxal (MGO), the most reactive precursor of advanced glycation end products (AGEs), has been implicated in vascular injury and neuro-retinal dysfunction. Its direct effects on retinal endothelial cells and underlying molecular mechanisms remain poorly understood

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue

<p dir="ltr">RNA sequencing files from pre-sorted and post-sorted fractions of different sources of EVs</p>

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Single-cell RNA sequencing

Introduction<p>Avian heterophils naturally lack myeloperoxidase (MPO), making chicken a unique evolutionary model for investigating MPO-independent innate immune strategies. However, the molecular programs governing heterophil maturation and activation remain largely unexplored.</p>Methods<p>Using single-cell RNA sequencing in a RAG1-deficient chicken model, we mapped heterophil maturation during

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Single-cell RNA sequencing

Introduction<p>Avian heterophils naturally lack myeloperoxidase (MPO), making chicken a unique evolutionary model for investigating MPO-independent innate immune strategies. However, the molecular programs governing heterophil maturation and activation remain largely unexplored.</p>Methods<p>Using single-cell RNA sequencing in a RAG1-deficient chicken model, we mapped heterophil maturation during

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue

<p dir="ltr">This dataset contains the non-redundant isoform GTF file of Ligusticum chuanxiong leaves, generated by FLAIR and SQANTI3 based on Oxford Nanopore long-read sequencing and publicly available short-read RNA-seq data. The file includes both annotated and novel isoforms from the two haplotypes (HapA and HapB) of L. chuanxiong.</p>

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue

Introduction<p>Sexual dimorphism in avian skeletal muscle is established during embryogenesis, but the stage-resolved transcriptional programs governing this process in geese remain largely unexplored.</p>Methods<p>To construct a stage-specific transcriptional atlas of muscle satellite cells (SMSCs), we performed histological examination and RNA sequencing of PAX7⁺ SMSCs isolated from m

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue

Objective<p>Pancreatic ductal adenocarcinoma (PDAC) exhibits profound molecular and metabolic heterogeneity associated with distinct phenotypic states. However, the contribution of transcription factor (TF)-driven regulatory programs to metabolic subtype stratification remains poorly understood. This study aims to determine whether TF-based classification can identify prognostically relevant glyco

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue

Objective<p>Pancreatic ductal adenocarcinoma (PDAC) exhibits profound molecular and metabolic heterogeneity associated with distinct phenotypic states. However, the contribution of transcription factor (TF)-driven regulatory programs to metabolic subtype stratification remains poorly understood. This study aims to determine whether TF-based classification can identify prognostically relevant glyco