Omics · study · 2026
EPHB2 Drives EMT-Linked Vasculogenic Mimicry and Cervical Cancer Progression via an ERK–ETV4 Transcriptional Program
Listed in NCBI GEO
To investigate the biological function EPHB2 in the cervical cancer, we established hela cell lines in which the EPHB2 gene has been knocked down by the small interfering RNA (siRNA) technique.
Description
Two different siRNAs targeting EPHB2 (KD) were used to knockdown EPHB2 expression in hela cells. A scrambled siRNA (NC) was used as a control.
For each sample, three independent biological replicates were performed. Then RNA-Seq experiment was performed by Shanghai Biotechnology Corporation (Shanghai, China).
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE326nnn/GSE326407 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326407 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1445209 ncbi.nlm.nih.gov/bioproject/PRJNA1445209 ↗
project · from NCBI GEO
- PubMed 42143313 pubmed.ncbi.nlm.nih.gov/42143313 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE326407 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |