Continuous manufacture of enabling formulations for a poorly soluble compound using hot melt extrusion technology

As a well-established technique in the production of oral solid dosage formulations, its operating capacity has the capability to address formulation and manufacturing issues associated with drugs which possess poor solubility, permeability and bioavailability. With traditional, batch-style manufacturing methods dominating the industrial production of oral solid dosage forms, and the associated high costs arising from its non-continuous processing structure and inefficiency, the industry welcomes ideas which generate increased efficiency and cost-effectiveness.

A concept which hot melt extrusion processing embodies.<br><br>The work presented in this thesis sought to further investigate the use of hot melt extrusion as a platform to manufacture enabling formulations i.e., formulations which can help make drugs bioavailable, using model small molecule compounds. Furthermore, the focus on issues which arise during processing of thermally labile drugs using hot melt extrusion technology have been examined.