Data · dataset · 2026
pone.0356818.t001 - <p> </p>
Listed in NCL Data
<div><p><i>Leishmania</i> CK1.2 (L-CK1.2) is a serine/threonine protein kinase essential for the survival of the protozoan parasite <i>Leishmania</i>, the causative agent of leishmaniasis.
Description
This study investigates the dynamic localization pattern of L-CK1.2 and the broad spectrum of its interacting partners within the parasite. Using proteomic analysis and confocal microscopy, we identified 230 L-CK1.2-associated proteins across the major parasite life stages.
This analysis revealed the ubiquitous presence of L-CK1.2 in various cellular structures, including the cytoskeleton, basal body, and flagellum. Using an <i>in vitro</i> system, sixty-four host proteins, involved in critical host biological processes such as immune response, apoptosis, and purine biosynthesis, were identified as potential interacting partners of L-CK1.2. These processes are known to be regulated by <i>Leishmania</i> during infection.
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The study highlights the potential dual function of L-CK1.2, in the parasite (<i>cis</i>) and within the host cell (<i>trans</i>), positioning this kinase as a key player in host-pathogen interactions. This work provides a comprehensive map of L-CK1.2 interactions and suggests its potential importance in regulating intracellular <i>Leishmania</i> survival, providing potential targets for leishmaniasis therapy. Furthermore, given the evolutionary conservation of CK1.2 across other parasitic organisms, our findings may have broader implications for understanding and managing parasitic infections.</p></div>
Links
Where it is published
- DOI doi.org/10.1371/journal.pone.0356818.t001 ↗
DOI / persistent id · from data ncl ac uk
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from data ncl ac uk
Topics
- From keywords
- Biochemistry and cell biology · Bioinformatics and computational biology · Earth & Environmental Science · Ecology · Immunology · Infectious diseases · Life Sciences · Medicine & Health · Microbiology
- Inferred from text
- Microscopy 75%
Provenance · 1 source records, 15 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCL Data | oai:figshare.com:article/34073853 | 12 h ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · data ncl ac uk | connector:data_ncl_ac_uk@1.0.0 | |
| concepts[field].anzsrc:field:320211 | mapping · data ncl ac uk | vocabulary-mapper@1.0.0 | keywords['Infectious Diseases'] |
| concepts[field].anzsrc:group:3101 | mapping · data ncl ac uk | vocabulary-mapper@1.0.0 | keywords['Cell Biology'] |
| concepts[field].anzsrc:group:3102 | mapping · data ncl ac uk | vocabulary-mapper@1.0.0 | keywords['Computational Biology'] |
| concepts[field].anzsrc:group:3103 | mapping · data ncl ac uk | vocabulary-mapper@1.0.0 | keywords['Ecology'] |
| concepts[field].anzsrc:group:3107 | mapping · data ncl ac uk | vocabulary-mapper@1.0.0 | keywords['Microbiology'] |
| concepts[field].anzsrc:group:3204 | mapping · data ncl ac uk | vocabulary-mapper@1.0.0 | keywords['Immunology'] |
| concepts[field].local:field:earth-environmental | mapping · data ncl ac uk | connector:data_ncl_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · data ncl ac uk | connector:data_ncl_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · data ncl ac uk | connector:data_ncl_ac_uk@1.0.0 | |
| concepts[modality].local:modality:microscopy | enrichment · data ncl ac uk | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · data ncl ac uk | connector:data_ncl_ac_uk@1.0.0 | /metadata/dc/description |
| license | source · data ncl ac uk | connector:data_ncl_ac_uk@1.0.0 | /metadata/dc/rights |
| publication_date | source · data ncl ac uk | connector:data_ncl_ac_uk@1.0.0 | |
| title | source · data ncl ac uk | connector:data_ncl_ac_uk@1.0.0 | /metadata/dc/title |