Data · dataset · 2026
Modified silicone elastomers to reduce capsular contracture
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.17034/32639508.v1
Capsular contracture is a common complication associated with breast implants following reconstructive or aesthetic surgery whereby a tight or constricting scar tissue capsule forms around the implant, often distorting the breast shape and resulting in chronic pain.
Description
Various structural modifications of the implant device and surgical strategies have been and/or are currently used to help reduce the incidence of capsular contracture.
The aim of this PhD project was to investigate a pharmacological approach to the modification of breast implant devices through the incorporation of various agents into the addition-cured silicone elastomer dispersions used to manufacture the shell component of the implants. Dexamethasone, simvastatin, triamcinolone acetonide, montelukast free acid and various copper and zinc substances (nanoparticles and salts) were the active agents selected for their anti-inflammatory, anti-fibrotic, and antibacterial properties.
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The physical and mechanical properties of the agent-loaded silicone samples were tested for hydrophobicity and tensile strength. In vitro release of the agents was characterised using high-performance liquid chromatography or inductively-coupled plasma optical emission spectroscopy and the antibacterial potential of those samples was measured on a S. aureus (ATCC 6538), and an E.coli (ATCC 25922) strain. The results obtained to date are encouraging and indicate the potential of incorporating of various pharmacological agents directly into breast implant devices for a local delivery to reduce the risks of severe capsular contracture.
Links
Where it is published
- DOI doi.org/10.17034/32639508.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
Provenance · 3 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32639508 | 5 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32639508 | 5 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32639508 | 5 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[field].anzsrc:field:400302 | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['Biomaterials'] |
| concepts[field].anzsrc:field:400302 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Biomaterials'] |
| concepts[field].anzsrc:field:400302 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Biomaterials'] |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |