Omics · study · 2026
Transcriptome changes in BMDM cells of Trex1 knockout mouse before and after STING antagonists treatments
Listed in NCBI GEO
Trex1 is known as a major cellular 3'-to-5' exonuclease which could digest both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini.
Description
Loss of Trex1 led to cell-intrinsic initiation of autoimmunity. Here, we investigated transcriptome changes in BMDM cells of Trex1 knockout mouse after STING antagonists (SN-011, H151) treatments.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE143nnn/GSE143826 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE143826 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA601782 ncbi.nlm.nih.gov/bioproject/PRJNA601782 ↗
project · from NCBI GEO
- PubMed 41773721 pubmed.ncbi.nlm.nih.gov/41773721 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE143826 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |