Omics · study · 2026
Interrogating DNA methylation associated with Lewy body pathology in a cross brain-region and multi-cohort study
Listed in NCBI GEO
In this study we investigated DNA methylation association with Lewy body pathology, profiled genome wide using this Illumina EPIC bead chip array in a set of brain samples sourced from the UK Brain Bank Network from centres at Newcastle, Imperial College London, University College London and Oxford.
Description
Data was generated from 779 samples, sourced from 406 unique donors (n = 387 Anterior Cingulate Cortex (ACC), n = 392 Prefrontal Cortex (PFC)).
Following quality control, linear modelling approaches were used to assess DNA methylation loci association with Lewy body pathology as measured by the Braak staging criteria. This data was meta analysed alongside two prior established cohorts (Netherlands Brain Bank and Brains for Dementia Research).
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE341nnn/GSE341563 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE341563 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1502935 ncbi.nlm.nih.gov/bioproject/PRJNA1502935 ↗
project · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Methylation profiling by genome tiling array
- From keywords
- Life Sciences
- Inferred from text
- Genetics 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE341563 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3105 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:methylation-profiling-by-genome-tiling-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |