Table 1_Prognostic value of the atherogenic index of plasma combined with lactate-to-albumin ratio for in-hospital mortality in patients with acute myocardial infarction complicated by cardiogenic shock.docx

LASSO identified six candidate predictors. Mechanical ventilation (OR = 10.10, 95% CI: 3.09–33.09, P < 0.001), LVEF <40% (OR = 3.49, 95% CI: 1.23–9.90, P = 0.019), AIP (OR = 4.30 per SD increase, P < 0.001), and LAR (OR = 1.88 per SD increase, P = 0.005) were independently associated with in-hospital mortality. The combined model showed good-to-excellent internal discrimination (AUC = 0.909, bootstrap 95% CI: 0.853–0.957), exceeding AIP (AUC = 0.777) or LAR (AUC = 0.735) alone.

Calibration was acceptable (Hosmer–Lemeshow P = 0.853; Brier score = 0.077, bootstrap 95% CI: 0.052–0.103). The model underwent internal validation only and should be considered hypothesis-generating pending external validation.</p>Conclusion<p>AIP and LAR were independently associated with in-hospital mortality and may reflect complementary lipid-metabolic and hypoperfusion-inflammatory pathways. The nomogram combines these biomarkers with hemodynamic and respiratory severity parameters and may support early risk stratification, but requires external multicenter validation before routine clinical use.</p>