Omics · study · 2026
DOT1L shapes ncPRC1-target gene repression to maintain cell identity of DLBCL [CUT&Tag]
Listed in NCBI GEO
DOT1L inhibition leads to a loss of H2AK119ub1 in different GC B-DLBCL cell lines.
Description
To determine whether this loss is global or gene specific, performed H2AK119ub1 and H3K27me3 CUT&Tag in the Oci-Ly7 cell line following six days of treatment with DMSO or DOT1Li. As reference, we used a doxycycline-inducible knockdown of USP7 due to its role in ncPRC1-mediated deposition of H2AK119ub1 in Oci-Ly7 cells.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327306 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327306 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1450391 ncbi.nlm.nih.gov/bioproject/PRJNA1450391 ↗
project · from NCBI GEO
Topics
- Stated by source
- Genome binding/occupancy profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE327306 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |