Neural network processing of holographic images

In order to successfully process real holograms, we find we must apply a series of image corrupting transformations and noise to the synthetic images used in training. In this evaluation, HolodecML had comparable position and size estimations performance to the standard processing method, but it improved particle detection by nearly 20 % on several thousand manually labeled HOLODEC images. However, the particle detection improvement only occurred when image corruption was performed on the simulated images during training, thereby mimicking non-ideal conditions in the actual probe.

The trained model also learned to differentiate artifacts and other impurities in the HOLODEC images from the particles, even though no such objects were present in the training data set. By contrast, the standard processing method struggled to separate particles from artifacts. HolodecML also leverages GPUs and parallel computing that enables large processing speed gains over serial and CPU-only based evaluation.

Our results demonstrate that the machine-learning based framework may be a possible path to both improving and accelerating hologram processing. The novelty of the training approach, which leveraged noise as a means for parameterizing non-ideal aspects of the HOLODEC detector, could be applied in other domains where the theoretical model is incapable of fully describing the real-world operation of the instrument and accurate truth data required for supervised learning cannot be obtained from real-world observations.