Excel · study · 2026
Lipid Metabolism Remodeling in Human Cardiomyocyte Differentiation and Maturation
Listed in NCBI GEO
During cardiac development, metabolic remodeling shifts from glycolysis-dependent energy production to fatty acid oxidation.
Description
Lipids serve as crucial energy substrates and structural components throughout heart formation and maturation. However, dynamic changes in endogenous lipid species during human cardiac development remain incompletely understood.
In this study, we profiled lipidomes of human embryonic stem cells (ESCs), mesoderm (MES), cardiac progenitors (CPCs), immature cardiomyocytes (CMs), and mature CMs derived from ESCs using high-performance liquid chromatography. Ceramide levels peaked at the CPC stage, implicating a key role in the MES-to-CPC transition. Meanwhile, lipid metabolites such as monosialodihexosylganglioside (GM3), phosphatidylcholine (PC), lysophosphatidylcholine (LPC), and lysophosphatidic acid (LPA) were markedly elevated in mature CMs.
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Integrated transcriptomic and chromatin accessibility analyses further defined lipid remodeling during CM differentiation. Functional assays revealed that LPA enhances beating rhythm stability in CPCs, whereas PC and LPA promote CM maturation. Collectively, these findings establish a comprehensive, dynamic lipidomic atlas of human cardiogenesis and provide a framework for understanding lipid-mediated regulatory mechanisms in heart development.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE310nnn/GSE310576 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE310576 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1366518 ncbi.nlm.nih.gov/bioproject/PRJNA1366518 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Biochemistry and cell biology 73% · Heart 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE310576 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[anatomy].local:anatomy:heart | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:3101 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (73%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |