Data · dataset · 2026
A Data-Driven Approach for the Development of a Time-Informed Adverse Outcome Pathway Network for the Cardiotoxicity of Environmental Chemicals
Listed in GRANTS Data and UP Research Data Repository — shown once because both records carry DOI 10.1021/acs.est.6c00396.s003
We developed a bottom-up, data-driven approach for constructing a time-informed adverse outcome pathway (AOP) network for environmental chemical-induced cardiotoxicity.
Description
Mechanistic end points were systematically extracted from 339 in vitro and in vivo studies, yielding 1759 Key Event (KE) entries and 4938 Key Event Relationship (KER) entries, together with study metadata and essentiality evidence from intervention experiments.
After quality filtering and minimum support thresholding, 62 unique KEs and 256 unique KERs were retained for network construction. Network analysis highlighted oxidative stress and mitochondrial dysfunction as prominent, highly connected KEs linking diverse upstream perturbations to downstream cardiomyocyte injury, inflammation, cardiac remodeling (fibrosis and hypertrophy), decreased myocardial contractility, and reduced left ventricular function.
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A central methodological finding was that temporal information was more informative at the level of KERs than at the level of KEs. The same KE could occur across multiple durations depending on the relationship in which it was embedded, whereas KER-level time-scale annotation resolved distinct acute, subacute, and chronic pathway patterns not apparent from KE timing alone. This framework provides an evidence-weighted synthesis of the most consistently supported cardiotoxicity mechanisms and introduces a temporal layer for the mechanistic interpretation of heterogeneous evidence.
Links
Where it is published
- DOI doi.org/10.1021/acs.est.6c00396.s003 ↗
DOI / persistent id · from grantsdata jst go jp
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from grantsdata jst go jp
Topics
- From keywords
- Biochemistry and cell biology · Biochemistry and cell biology · Cardiac remodeling · Cardiac remodeling · Chemistry · Chemistry · Earth & Environmental Science · Earth & Environmental Science · Engineering · Humanities · Infectious diseases · Infectious diseases · Life Sciences · Life Sciences · Medicine & Health · Medicine & Health · Social Science
- Inferred from text
- Heart 65%
Provenance · 2 source records, 23 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| GRANTS Data | oai:figshare.com:article/34059593 | 7 d ago | JSON v1 |
| UP Research Data Repository | oai:figshare.com:article/34059593 | 7 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · grantsdata jst go jp | connector:grantsdata_jst_go_jp@1.0.0 | |
| concepts[anatomy].local:anatomy:heart | enrichment · grantsdata jst go jp | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[disease].local:disease:cardiac-remodeling | mapping · grantsdata jst go jp | vocabulary-mapper@1.0.0 | keywords['cardiac remodeling'] |
| concepts[disease].local:disease:cardiac-remodeling | mapping · researchdata up ac za | vocabulary-mapper@1.0.0 | keywords['cardiac remodeling'] |
| concepts[field].anzsrc:field:320211 | mapping · grantsdata jst go jp | vocabulary-mapper@1.0.0 | keywords['Infectious Diseases'] |
| concepts[field].anzsrc:field:320211 | mapping · researchdata up ac za | vocabulary-mapper@1.0.0 | keywords['Infectious Diseases'] |
| concepts[field].anzsrc:group:3101 | mapping · researchdata up ac za | vocabulary-mapper@1.0.0 | keywords['Cell Biology'] |
| concepts[field].anzsrc:group:3101 | mapping · grantsdata jst go jp | vocabulary-mapper@1.0.0 | keywords['Cell Biology'] |
| concepts[field].local:field:chemistry | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · grantsdata jst go jp | connector:grantsdata_jst_go_jp@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · grantsdata jst go jp | connector:grantsdata_jst_go_jp@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:engineering | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:humanities | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · grantsdata jst go jp | connector:grantsdata_jst_go_jp@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · grantsdata jst go jp | connector:grantsdata_jst_go_jp@1.0.0 | |
| concepts[field].local:field:social-science | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| description | source · grantsdata jst go jp | connector:grantsdata_jst_go_jp@1.0.0 | /metadata/dc/description |
| license | source · grantsdata jst go jp | connector:grantsdata_jst_go_jp@1.0.0 | /metadata/dc/rights |
| publication_date | source · grantsdata jst go jp | connector:grantsdata_jst_go_jp@1.0.0 | |
| title | source · grantsdata jst go jp | connector:grantsdata_jst_go_jp@1.0.0 | /metadata/dc/title |