← Search

Omics · study · 2026

Role of DNMT3B in enhancer-transcriptional activities in molecular subtypes of acute myeloid leukemia.

Listed in NCBI GEO

Aberrant epigenetic regulation is a hallmark of acute myeloid leukemia (AML).

Description

Here, we investigated the molecular consequences of DNMT3B inhibition in KG1A cells, a model of immature AML, using an integrative multi-omics approach combining RNA-seq, Illumina EPIC DNA methylation arrays, ATAC-seq, and TMT-based quantitative proteomics.

Links

Get the data

Where it is published

Documentation and papers

Topics

Stated by source
Genome binding/occupancy profiling by high throughput sequencing · Homo sapiens
From keywords
Life Sciences
Inferred from text
Genetics 73% · Mass spectrometry 65% · RNA sequencing 65%
Provenance · 1 source records, 10 field assertions
SourceKeyLast seenRaw
NCBI GEOGSE29500114 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[field].anzsrc:group:3105enrichment · NCBI GEOtaxonomy-embedding@1.1.0title+keywords+description (73%)
concepts[field].local:field:life-sciencesmapping · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencingsource · NCBI GEOconnector:ncbi_geo@1.0.0/gdstype
concepts[modality].local:modality:mass-spectrometryenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (65%)
concepts[modality].local:modality:rna-seqenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (65%)
concepts[organism].NCBITaxon:9606source · NCBI GEOconnector:ncbi_geo@1.0.0/taxon
descriptionsource · NCBI GEOconnector:ncbi_geo@1.0.0/summary
publication_datesource · NCBI GEOconnector:ncbi_geo@1.0.0
titlesource · NCBI GEOconnector:ncbi_geo@1.0.0/title