Data · dataset · 2026
<b>Microgels Containing Protease Resistant CXCL12 and FasL Enable Long Term Allo-Islet Function Without Systemic Immunosuppression</b>
Listed in ZivaHub
<p dir="ltr">Type 1 diabetes (T1D) is a chronic disease characterized by the autoimmune destruction of insulin-producing beta cells in the pancreas.
Description
Replacement of beta cells by islet transplantation has proven to be successful in providing a functional cure for T1D. We have previously shown that microencapsulation of allo or xeno-islets with CXCL12 promotes beta cell function, provides immune protection, and facilitates vascularization at the graft site in both small and large animal models of T1D.
In addition, streptavidin-Fas Ligand (SA-FasL) microgels have been shown to induce immune acceptance of allogeneic islets through expansion of T regulatory cells (Tregs) in combination with short-term systemic immune suppression. This study evaluated a combination of these two complementary approaches for extending allo-islet graft survival in a mouse model of T1D through the co-delivery of SA-CXCL12 or a protease-resistant variant of the chemokine (SA-prCXCL12) and SA-FasL within biotinylated microgels in an allogeneic transplant setting.
Read the rest (1 more)
We demonstrated that microgels coated with SA-FasL and SA-prCXCL12, when co-transplanted with allogeneic islets, sustained long-term (6 months) diabetes reversal in STZ-treated mice without any systemic immunosuppression more effectively than either agent alone. Our findings demonstrate in this murine model of diabetes that microgels delivering a combination of SA-prCXCL12 and SA-FasL induces long-term local immune protection of the allo-islet graft, enhances intragraft Treg recruitment and improves graft vascularization while abrogating the need for any systemic immune suppression.</p>
Links
Where it is published
- DOI doi.org/10.2337/figshare.33369088.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Earth & Environmental Science · Life Sciences · Transplantation immunology
- Inferred from text
- Disease 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/33369088 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:field:320408 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Transplantation Immunology'] |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/rights |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |