Omics · study · 2026
Epigenetic control of CD8+ T cell tissue resident memory precursors differentiation by the histone methyltransferase SUV39H1 [Multiomics]
Listed in NCBI GEO
The molecular mechanisms of fate choices between circulatory and tissue-resident memory (TRM) cells upon CD8+ T cell activation, are still largely unknown.
Description
We show here that deletion of the histone methyltransferase SUV39H1 in CD8+ T cells, enhances homing to non-lymphoid tissues. At steady state, after space-induced proliferation or flu infection, SUV39H1-defective cells in tissues express CD49d and differentiate predominantly into CD69+/CD103- TRM.
Persisting SUV39H1-defective T cells in lungs are protective in flu re-infection and lung tumor models. Accumulation of SUV39H1-deficient TRM cells is due to increased proportions of TRM precursors with high stemness and TRM precursor potential. We conclude that SUV39H1 restrains CD69+ CD103- TRM commitment by inhibiting memory and stemness programs during CD8+ T cells effector differentiation.
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These results encourage the use of SUV39H1 depletion in the context of adoptive T cell therapies to optimize both the efficiency of target cell eradication and the long-term persistence of memory cells.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE308nnn/GSE308693 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE308693 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1332545 ncbi.nlm.nih.gov/bioproject/PRJNA1332545 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Genome binding/occupancy profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE308693 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].anzsrc:group:3105 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (72%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |