Data · dataset · 2026
Central Blockade of Cannabinoid CB1 and CB2 Receptors Increases Force Generation in Reserpine-Treated Mice, but Only CB1 Blockade Extends the Duration of Effort
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Motor impairment in parkinsonism extends beyond the classical triad to weakness and a reduced capacity to sustain motor output, whose neuromodulatory control is poorly resolved.
Description
The endocannabinoid system is a candidate regulator, but CB1 and CB2 receptors have not been separated within one preparation. Reserpine-treated adult female Swiss mice received vehicle, the CB1 antagonist AM251, or the CB2 antagonist AM630 into the lateral ventricle; catalepsy was recorded across three trials and neuromuscular performance in a grip force task.
Both antagonists increased the force generated at task onset, by amounts these data cannot distinguish: AM630 by 53.9 gf (95% CI 22.5–85.3) and AM251 by 41.2 gf (95% CI 8.8–73.6). They separated on duration. AM251 increased grip time by 619 ms (95% CI 113–1125), whereas AM630 did not (−70 ms, 95% CI −560 to +421).
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An interaction contrast on the force–time balance followed from that difference: AM630 shifted the balance toward force (−2.03 SD, <i>P</i> = 0.008), AM251 did not (−0.36 SD, <i>P</i> = 0.66), and the two differed from each other by 1.67 SD (<i>P</i> = 0.022). AM251 also reduced the odds of a cataleptic response (OR 0.16, 95% CI 0.03–0.89). Adjusting for body mass left both force effects unchanged.
The dissociation is therefore in the duration of effort rather than in its force: both antagonists raise force, and only CB1 blockade also extends the time over which it is maintained. Delivered intracerebroventricularly, these effects are central in origin but not anatomically localized.
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- DOI doi.org/10.1021/acsptsci.6c00206.s001 ↗
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- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
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Provenance · 1 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/34023313 | 13 d ago | JSON v1 |
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|---|---|---|---|
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| concepts[field].local:field:psychology-behavioral | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/rights |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |