Omics · study · 2026
Oxidation Polyethylene Microplastics Disrupt Lipid Transport in Aquatic Models: A Comparative Study Using Planktonic Crustacean and Zebrafish Embryo
Listed in NCBI GEO
Environmental aging processes, such as oxidation, can significantly alter the physicochemical properties and toxicity profiles of microplastics (MPs).
Description
Here, we investigated the toxicological impact of pristine polyethylene (PE) and oxidized polyethylene (OPE) microplastics using a dual-species aquatic model comprising Daphnia magna and zebrafish embryos. Characterization confirmed OPE particles exhibited increased surface roughness, higher surface charge, and broader size distribution compared to PE.
Exposure to OPE induced pronounced lipid accumulation and reduced heart rate in both models. Transcriptomic analysis revealed that OPE suppressed key lipid transport and metabolism genes, including mttp, apoea, and apobb. These effects were validated through qPCR and lipid staining techniques.
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Notably, zebrafish embryos exposed to OPE showed significant developmental impairment even with intact chorions, suggesting enhanced bioavailability of oxidized particles. This study highlights the amplified toxicity of aged microplastics and underscores the importance of evaluating environmentally relevant forms when assessing the ecological risk of MPs.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE304nnn/GSE304012 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE304012 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1298758 ncbi.nlm.nih.gov/bioproject/PRJNA1298758 ↗
project · from NCBI GEO
- PubMed 42252446 pubmed.ncbi.nlm.nih.gov/42252446 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Danio rerio · Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- Heart 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE304012 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[anatomy].local:anatomy:heart | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:7955 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |