Omics · study · 2026
Kupffer Cell-Derived IL-6 Aggravates Radiation-Induced Liver Disease by Activating Hepatocyte STAT3
Listed in NCBI GEO
Radiation-induced liver disease (RILD) is a serious complication of radiotherapy for upper abdominal tumors, the cellular and molecular basis of which remain mostly unclear.
Description
Sprague‒Dawley (SD) rats were exposed to a single dose of 30 gray (Gy) at a dose rate of 400 cGy/min on the right upper quadrant of the abdomen to induce liver injury in vivo. At 2 weeks after IR, Kupffer cells (KCs) characteristically expressed Il6.
IL-6 activated the JAK‒STAT signaling pathway in hepatocytes. However, the critical downstream target genes were unclear.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE293nnn/GSE293454 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE293454 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1244741 ncbi.nlm.nih.gov/bioproject/PRJNA1244741 ↗
project · from NCBI GEO
- PubMed 41783157 pubmed.ncbi.nlm.nih.gov/41783157 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Genome binding/occupancy profiling by high throughput sequencing · Rattus norvegicus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE293454 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10116 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |