Omics · study · 2026
Transcriptome profiling of human normal liver and hepatocellular carcinoma tissues stratified by EZH2 expression level
Listed in NCBI GEO
This RNA-seq dataset was generated to investigate transcriptomic alteriations associated with hepatocellular carcinoma(HCC) progression and the functional role of EZH2 expression.
Description
Liver tissue samples were collected from normal controls, HCC patients with low EZH2 expression, and HCC patients with high EZH2 expression. Differential gene expression analysis confirmed a marked increase in EZH2 expression in HCC relative to normal tissues and revealed transcriptional programs associated with proliferative and metastatic characterisrics that were progressively enhanced according to EZH2 expression level.
This dataset enables the exploration of EZH2-associated molecular signatures and their relevance to HCC malignancy and metastatic progression.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE312nnn/GSE312183 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE312183 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1372616 ncbi.nlm.nih.gov/bioproject/PRJNA1372616 ↗
project · from NCBI GEO
- PubMed 41622630 pubmed.ncbi.nlm.nih.gov/41622630 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Genetics 71% · RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE312183 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3105 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (71%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |