Data Sheet 1_The association between body composition and arterial stiffness: investigating the influence of inflammatory markers.pdf

Multivariable linear regression used robust standard errors and false-discovery-rate-adjusted p-values. Mediation analyses examined associations between body composition, arterial stiffness, and inflammatory markers, using 5,000 bootstrap samples.</p>Results<p>Visceral fat, total body fat, and fat mass index were positively associated with AIx: The adjusted regression coefficients were β = 0.642 (95% confidence interval, 0.172–1.112; p = 0.032) for visceral fat, β = 0.186 (95% confidence interval, 0.083–0.288; p < 0.001) for total body fat, and β = 0.333 (95% confidence interval, 0.157–0.508; p < 0.001) for fat mass index, respectively.

No bioimpedance-derived measure was independently associated with cfPWV or cPP after correction for multiple testing and no indirect associations through inflammatory markers were found.</p>Conclusion<p>Higher visceral fat, total body fat, and fat mass index were associated with higher AIx, but the selected inflammatory markers did not explain these cross-sectional associations. Longitudinal studies with broader biomarker panels are needed before causal or clinical conclusions can be drawn.</p>