Omics · study · 2026
Episignatures associated with 8-week combined physical exercise in women with obesity
Listed in NCBI GEO
Aims: Obesity is influenced by epigenetic mechanisms; however, little is known about DNA methylation markers associated with exercise-induced health-promotion interventions.
Description
This aims to explore the episignatures of an 8-week combined physical exercise training protocol on DNA methylation patterns in women with obesity. Patients and
Methods
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Thirteen women with obesity (BMI: 33 ± 2 kg/m²; age: 34 ± 5 years) underwent assessments of body composition, waist circumference, physical performance (VO₂max), and peripheral blood collection before and after an 8-week combined physical training intervention (3 sessions/week, 55 minutes/session, 70-90% maximum heart rate). DNA methylation was analyzed using the Illumina EPIC BeadChip. Results: The intervention improved clinical outcomes, including reduced waist circumference and increased VO₂max (p < 0.05).
Epigenome-wide analysis identified 15 differentially methylated regions, highlighting hypomethylation in SLFN11 and PM20D1 hypermethylation in GATA5. These genes are involved in pathways related to immune response, tumor suppression, thermogenesis, metabolic regulation, adiposity, glucose homeostasis, and transcriptional control. Conclusion: Combined physical training induced clinical improvements and DNA methylation changes in women with obesity, suggesting that exercise may alter the episignatures related to obesity.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328810 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328810 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1456580 ncbi.nlm.nih.gov/bioproject/PRJNA1456580 ↗
project · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Methylation profiling by array
- From keywords
- Life Sciences
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE328810 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[anatomy].local:anatomy:heart | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].anzsrc:group:3105 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (73%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:methylation-profiling-by-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |