Omics · study · 2026
Potential mechanisms of HOXA5 in AML by RNA-seq analysis
Listed in NCBI GEO
To explore the potential mechanisms of HOXA5 on AML, RNA-seq analysis was employed to evaluate the pattern of gene expressions in KG-1 cells with HOXA5 knockdown.
Description
Compared to the siNC group, the siHOXA5-1 group exhibited 757 differentially expressed genes (DEGs), of which 377 were upregulated and 380 were downregulated . The siHOXA5-2 group exhibited 801 DEGs, of which 387 were upregulated and 414 were downregulated.
Then, we identified the DEGs after both siHOXA5-1 and siHOXA5-2 treatments, and screened out 573 DEGS strictly regulated by HOXA5.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE304nnn/GSE304381 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE304381 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1301225 ncbi.nlm.nih.gov/bioproject/PRJNA1301225 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Genetics 72% · RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE304381 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3105 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (72%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |