Excel · study · 2026
Targeting ZIP12-mediated Zn2+ signaling as a treatment for pulmonary hypertension
Listed in NCBI GEO
ZIP12, a membrane bound zinc importer, is upregulated in the remodeled pulmonary arterioles of patients with pulmonary arterial hypertension (PAH).
Description
Genetic deletion of its encoding gene, slc39a12, ameliorates the disease in rodent models. We developed a humanized anti-ZIP12 monoclonal antibody, APL-9796, which showed dose-dependent efficacy and improved cardiopulmonary parameters of hypoxia-induced pulmonary hypertension in in humanized Slc39a12 rats.
Transcriptomic profiling revealed modulation of pathways including AMPK, PPAR, and PI3K-Akt signaling pathways. ZIP12-driven labile Zn2+ signaling underpins the pathogenesis of PAH.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE320nnn/GSE320567 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE320567 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1428837 ncbi.nlm.nih.gov/bioproject/PRJNA1428837 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Rattus norvegicus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE320567 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10116 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |