Neuropsychiatric Disorder

The score was fixed before evaluation, with target-ancestry effects excluded from training and tuning. GRCh37/hg19 coordinates, effect alleles, effective sample-size conventions, reproducible scripts, source citations, field definitions and SHA-256 checksums are included.</p><p dir="ltr">Archive</p><p dir="ltr">gsMap_NPD_Spatial_Data.zip</p><h2 dir="ltr">Description</h2><p dir="ltr">This dataset provides gsMap spatial-association results and candidate gene-expression data for the shared NPD genetic signal in the E16.5_E1S1 MOSTA mouse embryo reference.

It comprises 121,767 spatial spots across 25 tissue annotations and includes spot-level association statistics, regional Cauchy-combination results, candidate gene-specificity scores, normalized expression profiles, expression summaries, gene diagnostics and the exact GWAS input used in the analysis. Brain and spinal cord show the smallest regional Cauchy P values. The archive includes the author-supplied annotation mapping for the reported WIPF3 and BTN3A3 series, together with original source labels.

Run metadata distinguish the GWAS input used for these spatial results from the separately curated QC GWAS dataset. Data dictionaries, scripts for descriptive summaries and multiple-testing adjustment, source access information and SHA-256 checksums are supplied. Full spatial-transcriptomic and linkage disequilibrium reference databases remain available through their original providers.<br></p><p dir="ltr">Archive</p><p dir="ltr">NPD_H3_GWAS_Summary_Statistics.zip</p><h2 dir="ltr">Description</h2><p dir="ltr">This dataset contains Genomic SEM genome-wide association summary statistics for the higher-order H3 factor shared across major depressive disorder, post-traumatic stress disorder, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, schizophrenia, obsessive-compulsive disorder and panic disorder.

Component GWAS are of European ancestry. The source comprises 5,638,299 H3-SNP records. The archive separates 5,636,478 records passing documented numerical and model-estimation quality checks from 1,821 records carrying estimation warnings, and retains both sets with their diagnostic fields.

Effect estimates, standard errors, association statistics, alleles and GRCh37/hg19 positions are preserved. Effects are expressed on the marker-scaled H3 latent-factor scale. The implied sample-size field describes the model-derived effective information and is not an independent participant count.

The QC export script, original-source checksum, component-source citations, data dictionary and file-integrity manifest are included.</p>