Excel · study · 2026
Transcriptomic Profiling of RAW264.7 Cells During RANKL-Induced Osteoclast Differentiation
Listed in NCBI GEO
Osteoclast differentiation is primarily driven by RANKL stimulation, yet the transcriptional remodeling associated with this process remains incompletely characterized.
Description
This dataset profiles global gene expression changes in RAW264.7 macrophages under two conditions: untreated control and RANKL-induced osteoclast differentiation. The transcriptomic comparison reveals key pathways associated with osteoclast formation, including osteoclast-related gene activation, metabolic remodeling, and oxidative stress–related signaling.
These data serve as the baseline reference for subsequent uridine-intervention analyses.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE311nnn/GSE311709 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE311709 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1370319 ncbi.nlm.nih.gov/bioproject/PRJNA1370319 ↗
project · from NCBI GEO
- PubMed 42125660 pubmed.ncbi.nlm.nih.gov/42125660 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Genetics 71%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE311709 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3105 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (71%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |