Additional file 2 of Alzheimer’s disease polygenic risk, APOE ε4 dose, and accelerometer-derived circadian rest–activity rhythms in relation to incident dementia and Alzheimer’s disease in UK Biobank: a prospective cohort study

APOE genotype-category sensitivity analysis. Cross-sectional models comparing ε2/4, ε3/4, and ε4/4 groups with non-carriers, plus analyses excluding ε2/4. Table S3.

European-only cross-sectional models. Regression outputs restricted to ancestry_group = 1. Table S4.

IS/IV model diagnostics. Dropped covariates and diagnostics under QC ≥ 240 30-min bins. Table S5.

Full Cox model outputs. Fully adjusted Cox outputs for incident dementia and incident Alzheimer’s disease. Table S6.

ICD-10 code lists. Codes used for dementia and Alzheimer’s disease definitions (broad and strict). Table S7.

Incident interaction analyses. Fully adjusted Cox models for RA × AD-PRS and RA × APOE ε4 dose in incident dementia and broad Alzheimer’s disease; all interaction p values are nominal. Table S8.

Mutual-adjustment sensitivity analysis. Cross-sectional models including both AD-PRS and APOE ε4 dose for RA and phase-timing outcomes. Table S9.

Accelerometry subcohort comparison. Baseline comparison of participants included in versus excluded from the accelerometry analytic cohort, used for the inverse-probability-weighted selection analysis.