Omics · study · 2026
Stathmin 1 regulates mitophagy and cellular function in hematopoietic stem and progenitor cells
Listed in NCBI GEO
Stathmin 1 is a cytoplasmic phosphoprotein that regulates microtubule dynamics via promotion of microtubule catastrophe and sequestration of free tubulin heterodimers.
Description
Stathmin expression is a feature of proliferating cells, and it is overexpressed in many cancers, including hematopoietic malignancies. In contrast to its roles in proliferating cells, considerably less is known of Stathmin 1 in quiescent cells.
Notably, Stathmin 1 is highly expressed in hematopoietic stem and progenitor cells (HSPCs), and herein we found that loss of Stathmin 1 is associated with altered microtubule architecture and markedly impaired HSPC function. Transcriptomic studies suggested alterations in oxidative phosphorylation in Stmn1-/- HSPCs, and further mechanistic studies revealed defective mitochondrial structure and function in the absence of Stathmin 1 with increased ROS production.
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Microtubules associate with mitochondria and lysosomes to facilitate autophagosome formation and mitophagy, and indeed we found that this critical mitochondrial quality control process is impaired in Stathmin 1-deficient HSPCs. Finally, stimulation of autophagy improved the colony forming ability of Stmn1-/- HSPCs. Together, these data identify a novel, non-proliferative role for Stathmin 1 in the regulation of HSPC mitochondrial quality control and cellular function.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328105 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328105 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1453927 ncbi.nlm.nih.gov/bioproject/PRJNA1453927 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE328105 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |