Naoxintong Capsule inhibits endothelial cell injury by regu-lating the generation and function of circulating exosomes

It has been shown that the pre-progression of cardiovascular disease is usually ac-companied by endothelial injury, oxidative stress and inflammatory responses, so attention to the protection of injured endothelium is particularly important for the early control and treatment of vascular disease. Circulating exosomes belong to a type of extracellular vesicles with substance transport and signaling roles that act as regulatory mediators and play a great advantage in various diseases treatment.

Naoxintong capsule (NXT) is a Chinese medicine with good clinical efficacy in alleviating the progression of cardiovascular diseases. However, the role of circulating exosomes in the treatment of endothelial injury by NXT remains unexplored. Here, we reported the protective effect of NXT on endothelial damage through circulating exosomes.