Data · dataset · 2025
Proteins identified from tumor-derived extracellular vesicles using mass spectrometry
Listed in DataCite
Tumor-derived extracellular vesicles (tEVs) are important communication tools used by tumor cells to impact the function of other cells in the body.
Description
Accumulating evidence indicate that tEVs could impair the ability of immune cells in effectively attacking cancer cells. In our study, we find that proteins carried in tEVs are crucial for the immune-suppressive function of tEVs.
In this study, we identified the proteins present in tEVs isolated from three different tumor cell lines: MCF7, A375, and A549. Proteins were extracted from the isolated tEVs, digested with trypsin, and analyzed by LC-MS/MS to identify the proteins. The identified proteins are listed in this dataset.
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Among the proteins identified, a total of 321 proteins were shared in all three tEVs, indicating tEVs use a core set of proteins to exert their suppressive function.
Links
Where it is published
- Repository landing page datadryad.org/dataset/doi:10.5061/dryad.9s4mw6mrv ↗
landing page · from DataCite
- DOI doi.org/10.5061/dryad.9s4mw6mrv ↗
DOI / persistent id · from DataCite
Documentation and papers
- Creative Commons Zero v1.0 Universal creativecommons.org/publicdomain/zero/1.0/legalcode ↗
license · from DataCite
- IsCitedBy 10.1126/scitranslmed.adm7269 doi.org/10.1126/scitranslmed.adm7269 ↗
publication · from DataCite
Catalogue records · 2
- DataCite API api.datacite.org/dois/10.5061/dryad.9s4mw6mrv ↗
metadata API · from DataCite
- DataCite Commons commons.datacite.org/doi.org/10.5061/dryad.9s4mw6mrv ↗
catalogue entry · from DataCite
Topics
- Stated by source
- Basic medicine
- From keywords
- Mass spectrometry
- Inferred from text
- Cancer 75% · Oncology and carcinogenesis 70%
Provenance · 1 source records, 12 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| DataCite | 10.5061/dryad.9s4mw6mrv | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · DataCite | connector:datacite@1.0.0 | /data/attributes/rightsList |
| byte_size | source · DataCite | connector:datacite@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · DataCite | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:3211 | enrichment · DataCite | taxonomy-embedding@1.1.0 | title+keywords+description (70%) |
| concepts[field].fos:basic-medicine | source · DataCite | connector:datacite@1.0.0 | |
| concepts[modality].local:modality:mass-spectrometry | mapping · DataCite | vocabulary-mapper@1.0.0 | keywords['Mass spectrometry'] |
| created_date | source · DataCite | connector:datacite@1.0.0 | |
| description | source · DataCite | connector:datacite@1.0.0 | /data/attributes/descriptions |
| license | source · DataCite | connector:datacite@1.0.0 | /data/attributes/rightsList |
| publication_date | source · DataCite | connector:datacite@1.0.0 | /data/attributes/dates |
| title | source · DataCite | connector:datacite@1.0.0 | /data/attributes/titles/0/title |
| version_label | source · DataCite | connector:datacite@1.0.0 |