Omics · study · 2026
Hypoxia induced alternative splicing transcript DGKG Δ exon13 promotes glioblastoma progression
Listed in NCBI GEO
Glioblastoma (GBM) is one of the most malignant types of central nervous system tumors.
Description
Oxygen deprivation in the tumor microenvironment is thought to be an important factor in promoting GBM progression. We found that new transcript DGKG Δ exon13 was generated in GBM under hypoxia via alternative splicing.
Moreover, the results of CCK8, Transwell and Matrigel-transwell experiments showed that the proliferation, migration and invasion abilities of U87-MG and T98G were decreased after DGKG knockdown. Compared to wild-type DGKG, DGKG Δexon13 overexpressing significantly promoted cellular proliferation, migration and invasion abilities in GBM.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE275nnn/GSE275660 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE275660 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1152516 ncbi.nlm.nih.gov/bioproject/PRJNA1152516 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE275660 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |