Omics · study · 2026
The Role of CAPNS1 in Mitochondrial Function and Synaptic Plasticity of Alzheimer's Disease
Listed in NCBI GEO
Alzheimer's disease (AD), a neurodegenerative disorder, is marked by brain atrophy.
Description
Beyond the recognized and dominant amyloid cascade hypothesis, mitochondrial dysfunction contributes to AD progression. Improving mitochondrial function has been found to rescue cognitive deficits in AD.
However, the relevant mechanisms are poorly understood. Our study revealed decreased levels of calpain small subunit 1 (CAPNS1) levels in AD, which was correlated with mitochondrial dysfunction and synaptic loss. This study demonstrated that CAPNS1 regulated mitochondrial DNA (mtDNA) expression by activating the Ca2+-CaMKⅡβ-MAPK-PGC-1α axis, thereby improving mitochondrial function.
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In addition, CAPNS1 upregulation in the APP/PS1 mice improved synaptic plasticity and cognitive function. Collectively, CAPNS1, as a pivotal regulator of mitochondrial function, alleviated synaptic loss and cognitive defect in AD.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE329nnn/GSE329819 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE329819 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1461895 ncbi.nlm.nih.gov/bioproject/PRJNA1461895 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE329819 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |