Excel · study · 2026
Effects of TGFbeta1/2/3 deletion in cardiomyocytes on fibroblast programming
Listed in NCBI GEO
Transforming growth factor β (TGFβ) is a secreted growth factor that, during development and injury, influences fibroblasts to differentiate and synthesize ECM and matricellular proteins.
Description
We observed that deletion of Tgfb1, Tgfb2, Tgfb3 genes (TGFβ ligands) from cardiomyocytes early during development results in cardiac dysfunction by 6 weeks of age with altered fibroblast activity and altered ECM content. The goal of this project was to elucidate the changes, at the transcriptional level, in cardiac fibroblasts from triple knockout (TKO) hearts lacking expression of TGFbeta1/2/3 in cardiac myocytes.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE298nnn/GSE298104 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE298104 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1268350 ncbi.nlm.nih.gov/bioproject/PRJNA1268350 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Heart 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE298104 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[anatomy].local:anatomy:heart | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |