Omics · study · 2026
Effect of depletion of NAMPT in human endothelial cells (B4G12)
Listed in NCBI GEO
In our study, NAMPT was found downregulated In the corneal endothelium of patients with Fuchs endothelial corneal dystrophy.
Description
In this study, NAMPT was knocked down in the human corneal endothelial cell line (B4G12), and significant decreases in corneal endothelial cell viability, as well as the activation of immune-related pathways and extracellular matrix remodeling pathways, were observed. These changes are consistent with the expression profile of corneal endothelium in FECD patients, suggesting that downregulation of NAMPT plays an important role in the pathogenesis of FECD.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE319nnn/GSE319606 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE319606 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1424717 ncbi.nlm.nih.gov/bioproject/PRJNA1424717 ↗
project · from NCBI GEO
- PubMed 42206947 pubmed.ncbi.nlm.nih.gov/42206947 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE319606 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |