Omics · study · 2026
Endothelial miR-33 protects from atherosclerotic lesion initiation and acute inflammation
Listed in NCBI GEO
Human aortic endothelial cells (HAEC) were treated with TNF, or TNF and LDL, in order to determine how cholesterol loading influences HAEC inflammatory responses to TNF.
Description
Cells were also transfected with a miR-33 mimic to determine which of the LDL-mediated perturbations are dependent on cholesterol-induced miR-33 dysregulation. From these analyses, we determined that miR-33 is able to rescue a signifcant portion of the genes dysregulated in hypercholesteremic inflammation compared to normocholesteremic inflammation.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE299nnn/GSE299560 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE299560 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1274983 ncbi.nlm.nih.gov/bioproject/PRJNA1274983 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE299560 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |