Omics · study · 2026
Splice isoforms of the histone variants macroH2A1 differentially regulate hippocampal gene expression and memory formation
Listed in NCBI GEO
Histone variants are critical components of neural chromatin and emerging regulators of long-term memory formation and neural gene expression.
Description
We previously showed that deleting the macrodomain-bearing histone macroH2A1 in mouse hippocampus impairs long-term memory. Here, we expand on this finding by discriminating between alternative splice isoforms of mH2A1, mH2A1.1 and mH2A1.2, which bear structurally distinct macrodomains.
We characterized the genomic localization of mH2A1.1 and mH2A1.2 using isoform-specific antibodies, and evaluated the effects of isoform-specific knockdown via shRNA on hippocampal transcription and hippocampal-dependent memory.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE332nnn/GSE332710 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE332710 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1468969 ncbi.nlm.nih.gov/bioproject/PRJNA1468969 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Genome binding/occupancy profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Genetics 69%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE332710 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3105 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (69%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |