Design, synthesis and evaluation of amphibian isolated peptides as antibacterial and antiproliferative agents

These peptides were chemically synthesised using the solid phase peptide synthesis method once the primary structure obtained. The synthesised peptides were identified and purified by MALDI-TOF MS and RP-HPLC. Several bioassays were performed to evaluate their bioactivities.<br><br>Targeted modifications were designed based on the results which included increasing cationicity and hydrophobicity of the peptides, elimination of the highly conserved regions and modifications of the motif of the peptides such as the C-terminal amidation to study the structure-function relationships. <br><br>The results of this study brought some ideas on the targeted modifications of AMPs.

These modifications improve the bioactivities of peptides which may be developed as potential therapeutic agents. <br><br><i>Thesis embargoed until 31 December 2026</i>.