Supplemental Material for: Clinical Course and Prognosis of the Global Leadership Initiative on Malnutrition-defined Malnutrition in Critically Ill Patients with Sepsis: A Multicenter Prospective Observational Study

This was a multicenter prospective study conducted at 15 centers. Malnutrition was identified at ICU admission when both phenotypic and etiologic criteria were present. The primary outcome was a composite of in-hospital mortality or a decline in activities of daily living (Barthel Index <90) at discharge.

Secondary outcomes included ICU length of stay, use of parenteral nutrition, and days to achievement of each ICU Mobility Scale level. Results: Among 254 patients, 106 (41.7%) had malnutrition. The malnutrition group showed a significantly higher occurrence of the composite of in-hospital mortality and Barthel Index <90 (76.4% vs. 64.2%, p=0.04) and had significantly longer ICU stays (7 vs. 5, p=0.001).

Total nutrition delivery did not significantly differ between groups, while a higher percentage of patients in the malnutrition group received parenteral nutrition (57.6% vs. 43.2%, p=0.02). Significant delays in achieving higher mobility levels were observed in the malnutrition group. Conclusions: GLIM-defined malnutrition in patients with sepsis was significantly associated with the composite outcome of in-hospital mortality or Barthel Index <90 at discharge.

These results suggest the clinical importance of an early GLIM assessment after ICU admission.</p>