Data · dataset · 2026
Effectiveness of switching from reference adalimumab to biosimilar adalimumab-atto in patients with chronic non-infectious uveitis
Listed in ZivaHub and Deakin Research Online — shown once because both records carry DOI 10.6084/m9.figshare.34031150.v1
<p>Limited real-world studies have evaluated outcomes after switching treatment from a reference product (RP) to a biosimilar product in noninfectious uveitis (NIU).
Description
The objective of this real-world study was to assess the outcomes of switching from RP adalimumab to biosimilar adalimumab-atto in the United States.</p> <p>This retrospective pre-post study included adults with NIU stable on RP adalimumab who were switched to adalimumab-atto and followed for up to six months.
Outcomes included the use of systemic and local high-dose corticosteroids, analyzed using interrupted time series analyses, and changes in visual acuity among patients with both pre- and post-switch acuity measurements.</p> <p>190 patients were included, with a mean age of 50.5 ± 16.0 years, 61.1% female, and a mean disease duration of 6.5 ± 6.3 years prior to switching. There was no statistically significant trend in usage of either systemic or local high-dose corticosteroid after the switch (<i>p</i> = 0.33 and <i>p</i> = 0.36, respectively).
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There was no change in vision acuity (<i>n</i> = 110, <i>p</i> = 0.61).</p> <p>The lack of change in systemic or local high-dose corticosteroid use following the switch from RP adalimumab to adalimumab-atto suggests that the switch may be effective and safe in adult patients with NIU.</p>
Links
Where it is published
- DOI doi.org/10.6084/m9.figshare.34031150.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Earth & Environmental Science · Earth & Environmental Science · Ecology · Ecology · Immunology · Immunology · Infectious diseases · Infectious diseases · Life Sciences · Life Sciences · Medicine & Health · Medicine & Health · Social Science · Social Science · Sociology · Sociology · Virology · Virology
- Inferred from text
- Disease 75%
Provenance · 2 source records, 24 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/34031150 | 13 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/34031150 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:field:310706 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Virology'] |
| concepts[field].anzsrc:field:310706 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Virology'] |
| concepts[field].anzsrc:field:320211 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Infectious Diseases'] |
| concepts[field].anzsrc:field:320211 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Infectious Diseases'] |
| concepts[field].anzsrc:group:3103 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Ecology'] |
| concepts[field].anzsrc:group:3103 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Ecology'] |
| concepts[field].anzsrc:group:3204 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Immunology'] |
| concepts[field].anzsrc:group:3204 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Immunology'] |
| concepts[field].anzsrc:group:4410 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Sociology'] |
| concepts[field].anzsrc:group:4410 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Sociology'] |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:social-science | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:social-science | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/rights |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |