Nuclear myosin 1 regulates platelet activation and immune response in mice

This process is mostly regulated by specific expression of multiple genes which guide the cell through the differentiation process but also ensure proper function of terminal cell types. Over the last decade, the role of cellular metabolism in maintaining the pluripotency of stem cells and subsequent differentiation is getting more attention as there is a direct link between the metabolic status of cells and their differentiation potential.

We have recently shown that deletion of Nuclear Myosin 1 (NM1) leads to a molecular switch from oxidative phosphorylation to glycolysis and subsequent tumorigenesis in mice. Here we performed an in vitro analysis of metabolomic profiles associated with NM1 loss and measured the cytokine and chemokine levels in cells to provide evidence for a possible role of NM1 during hematopoiesis. Moreover, we explored the role of NM1 during the differentiation of hematopoietic progenitor stem cells to terminal blood cells by transcriptomic analysis of bone marrow, spleen, and peripheral blood.