Data · dataset · 2023
Causal relationship between the use of lipid-lowering drugs and the risk of cholelithiasis: A two-sample Mendelian randomized study
Listed in ScienceDB
Objective The primary aim of this investigation was to explore the potential causal association between the utilization of lipid-lowering drugs and the incidence of cholelithiasis.
Description
Methods
A two-sample Mendelian Randomization (MR) study was executed, deploying single nucleotide polymorphisms (SNPs) associated with lipid-lowering drug usage as instrumental variables. The principal analytical approach employed was the inverse variance weighting method, complemented by the MR-Egger regression model, weighted median analysis method, simple mode method, and weighted mode method as supplementary analysis methodologies.
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Two-sample MR was utilized to assess the causal impact of lipid-lowering drug usage on the risk of cholelithiasis. Heterogeneity testing, pleiotropic testing, and sensitivity analysis were employed to assess the robustness and stability of the outcomes.Results The findings revealed a statistically significant causal link between the administration of lipid-lowering drugs and the diminished risk of cholelithiasis (OR = 0.17, 95% CI = 0.04-0.75, P = 0.019).
Heterogeneity was observed in this investigation (I2 = 95%, P < 0.05), yet no evidence of pleiotropic bias was discerned in the analysis results (intercept term was -0.003, P = 0.866). Sensitivity analysis corroborated the robustness of the MR analysis outcomes.Conclusion In conclusion, the utilization of lipid-lowering drugs appears to be associated with a statistically significant reduction in the risk of cholelithiasis.
Links
Where it is published
- DOI doi.org/10.57760/sciencedb.o00130.01045 ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Social Science
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.o00130.01045 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license_text | source · scidb cn | connector:scidb_cn@1.0.0 | |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |