Table 1_Association between perioperative factors and the occurrence of postoperative cerebellar mutism syndrome in children.docx

Intra- and perioperative factors such as the surgical approach; the extent of resection; the administration of dexamethasone, blood products, coagulative factors, and mannitol; the use of a preoperative cerebrospinal fluid (CSF) drain; and postoperative sodium and hemoglobin levels were examined.</p>Results<p>Crude-effect analysis showed associations between pCMS and medulloblastoma histology (odds ratio [OR] = 7.40, 95% confidence interval [CI] = [1.75, 31.17]) and the administration of blood products (OR = 4.82, 95% CI = [1.15, 20.16]).

Moreover, there was a significant association between the occurrence of pCMS and hemoglobin (OR = 0.55, CI = [0.31, 0.96]) and sodium (OR = 1.21, 95% CI = [1.00, 1.46]) levels on postoperative day 1. Multivariate analysis confirmed the association with medulloblastoma histology (OR = 4.66, 95% CI = [1.13, 19.15]).</p>Conclusion<p>In multivariate analysis, histology was the only significant factor for the development of pCMS.

Nonetheless, there was a trend suggesting that the administration of blood products and the postoperative hemoglobin and sodium levels could represent risk factors for development of pCMS in this explorative analysis.</p>