Table 1_Low-density lipoprotein cholesterol modulates amyloid-related entorhinal vulnerability and episodic memory performance in older adults.docx

The unconditional indirect statistical association was supported (β = −0.0329, 95% bias-corrected bootstrap CI [−0.0647, −0.0072]). LDL-C modified the Aβ–EC association (β = −0.0937, HC3 SE = 0.0332, 95% CI [−0.1589, −0.0285], p = 0.0049), although the incremental explanatory magnitude was small (ΔR² = 0.0082). The conditional Aβ–EC association was unsupported at approximately 66 mg/dL LDL-C (β = 0.0263, p = 0.583), not statistically supported at approximately 100 mg/dL (β = −0.0639, p = 0.060), and negative at 138 mg/dL (β = −0.1648, p < 0.001).

The index of moderated indirect association was supported (β = −0.0357, 95% bias-corrected bootstrap CI [−0.0637, −0.0119]); conditional indirect associations were most clearly supported at higher LDL-C levels. A similar interaction was observed for non-HDL cholesterol, suggesting that the pattern may reflect a broader atherogenic lipid context.</p>Conclusion<p>Circulating LDL-C was associated with modest heterogeneity in the cross-sectional Aβ–EC relationship, with more clearly negative conditional associations observed at higher LDL-C levels.

Longitudinal studies are needed to determine the temporal and clinical relevance of these findings.</p>