Data Sheet 1_Associations of lipid metabolic parameters with cumulative live birth rate in PCOS patients undergoing IVF/ICSI and development of a nomogram-based predictive model.pdf

Internal validation employed bootstrap resampling with 1,000 iterations. Model performance was assessed by AUC, calibration curves, and decision curve analysis. A nomogram was constructed for clinical application.</p>Result<p>Multivariate analysis identified high-quality embryo rate (OR = 1.025, 95% CI: 1.010–1.041, P = 0.001) and high-quality blastocyst rate (OR = 1.014, 95% CI: 1.002–1.026, P = 0.025) as independent protective factors.

Elevated triglycerides (TG) (OR = 0.734, 95% CI: 0.555–0.969, P = 0.029) and higher BMI (OR = 0.915, 95% CI: 0.838–1.000, P = 0.049) were independent risk factors for reduced CLBR. The model achieved AUCs of 0.804 and 0.760 in the training and validation sets, respectively. Calibration was satisfactory (Brier score = 0.152), and DCA confirmed positive net benefit.</p>Conclusion<p>Dyslipidemia, primarily elevated TG, is independently associated with lower CLBR in PCOS patients undergoing IVF/ICSI.

Our nomogram incorporates TG, apolipoprotein A, BMI, trigger-day estradiol and progesterone, high-quality embryo rate and high-quality blastocyst rate. This tool may serve as a foundation for future external validation and exploratory risk stratification, though clinical application requires prospective multicenter studies.</p>