Omics · study · 2026
Targeting TRIM24 promotes neuroblastoma differentiation and decreases tumorigenicity via LSD1/CoREST complex
Listed in NCBI GEO
High-risk neuroblastoma (NB) still has an unfavorable prognosis and inducing NB differentiation is a potential strategy for clinical treatment, yet underlying mechanisms are still elusive.
Description
Here we identify TRIM24 as an important regulator of NB differentiation. Trim24 was highly expressed in spontaneous NB in TH-MYCN transgenic mice and clinical NB specimens.
And it was associated with poor NB differentiation and functioned as an unfavorable prognostic factor. Knockout of TRIM24 in MYCN-amplified neuroblastoma cells promoted cell differentiation and reduced cell stemness, cell colony formation in soft agar and subcutaneous xenograft tumor growth in nude mice. Mechanistic investigations demonstrated that TRIM24 knockout activated retinoic acid pathway and suppressed LSD1/CoREST complex formation and inhibited the transcription of genes involved in NB differentiation such as ZIC4.
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Targeting TRIM24 in combination with retinoic acid (RA) synergistically promoted NB cell differentiation and inhibited cell viability. Taken together, Our findings demonstrate that TRIM24 is critical for NB differentiation and suggest that TRIM24 is a promising therapeutic target in combination with RA in NB differentiation therapy.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE227nnn/GSE227066 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE227066 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA943152 ncbi.nlm.nih.gov/bioproject/PRJNA943152 ↗
project · from NCBI GEO
- PubMed 37466744 pubmed.ncbi.nlm.nih.gov/37466744 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE227066 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |