Text · study · 2026
Spatial transcriptomics reveals D2-associated synaptic transcriptional attenuation in the chronically stressed dorsal striatum
Listed in NCBI GEO
Chronic stress alters striatal functions involved in motivation, action selection, and behavioral adaptation, yet cell-type-associated transcriptional organization in the dorsal striatum remains unclear.
Description
We used RNAscope-guided GeoMx spatial transcriptomics to compare D1- and D2-enriched neuronal compartments within anatomically matched dorsal striatal regions after chronic restraint stress. Chronic restraint stress engaged both populations and produced comparable numbers of differentially expressed genes.
Pathway-level analysis revealed partially overlapping transcriptional attenuation in D1 and D2 neurons, whereas D2 responses showed more coherent organization around receptor-trafficking and synaptic signaling programs. CRS-downregulated D2 genes further resolved into synapse-centered functional categories, including glutamatergic synapse, postsynaptic organization, and dendritic spine.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE337nnn/GSE337812 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE337812 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1491132 ncbi.nlm.nih.gov/bioproject/PRJNA1491132 ↗
project · from NCBI GEO
Topics
- Stated by source
- Mus musculus · Other
- From keywords
- Life Sciences
- Inferred from text
- Biochemistry and cell biology 68%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE337812 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3101 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (68%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |