Table · dataset · 2026
Synapse-enriched lncRNAs are required for local translation and hippocampal-dependent fear memory
Listed in HKU DataHub and figshare and Loughborough Research Repository — shown once because both records carry DOI 10.6084/m9.figshare.34004685.v1
Description
<p dir="ltr">Studies on neuronal long noncoding RNAs (lncRNAs) have remained predominantly nucleus-centric, leaving the identity and the functional landscape of synapse-enriched lncRNAs underexplored.We identify 95 synapse-enriched lncRNAs in the adult mouse hippocampus and outline the physiological roles of the synaptic lncRNAs Pvt1,Pantr1and a previously uncharacterized synaptic lncRNA 241000H16Rik (which we call SynLAMP), in contexts of synapse development, synaptic plasticity and memory.
Pvt1 exclusively regulates excitatory synapse development, and its synapse-specific loss alters synaptic activity keeping fear-memory unaltered. Contrastingly, SynLAMP demonstrates a more synapse-centric role in activity-dependent translation and fear memory. Fear-conditioning enhances SynLAMP abundance in the dendrites, where it promotes local translation by sequestering the translation inhibitor FUS.
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Synaptic loss of SynLAMP, or disruption in its FUS interaction impairs fear-memory and the activity-dependent local translation of CaMK2α, a FUS target. Enhanced allocation of SynLAMP to the synapse and its dynamic interaction with FUS suggests that SynLAMP behaves as an activity-dependent, synapse-localized molecular decoy that bolsters fear memory. Collectively, this study provides a mechanistic introspection on the pervasive influence of synapse-localized lncRNAs in aspects of synapse development, activity-dependent local translation, and memory formation, highlighting a stronger demand to understand the role of localized lncRNAs in broader cellular contexts.</p>
Links
Where it is published
- DOI doi.org/10.6084/m9.figshare.34004685.v1 ↗
DOI / persistent id · from datahub hku hk
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from datahub hku hk
Topics
- From keywords
- Astronomy & Astrophysics · Behavioural neuroscience · Behavioural neuroscience · Behavioural neuroscience · Chemistry · Chemistry · Computer Science & AI · Computer Science & AI · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Economics & Finance · Economics & Finance · Engineering · Engineering · Humanities · Humanities · Life Sciences · Life Sciences · Life Sciences · Materials Science · Mathematics & Statistics · Medicine & Health · Medicine & Health · Ocean & Atmospheric Science · Psychology & Behavioral Science · Psychology & Behavioral Science · Psychology & Behavioral Science · Social Science · Social Science
Provenance · 3 source records, 35 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| HKU DataHub | oai:figshare.com:article/34004685 | 5 d ago | JSON v1 |
| figshare | oai:figshare.com:article/34004685 | 4 d ago | JSON v1 |
| Loughborough Research Repository | oai:figshare.com:article/34004685 | 4 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].anzsrc:field:520202 | mapping · datahub hku hk | vocabulary-mapper@1.0.0 | keywords['Behavioural neuroscience'] |
| concepts[field].anzsrc:field:520202 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Behavioural neuroscience'] |
| concepts[field].anzsrc:field:520202 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Behavioural neuroscience'] |
| concepts[field].local:field:astronomy | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:engineering | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:engineering | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:humanities | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:humanities | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:materials-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:mathematics-statistics | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:ocean-atmospheric | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:psychology-behavioral | mapping · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].local:field:psychology-behavioral | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:psychology-behavioral | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:social-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| description | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | /metadata/dc/description |
| license | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | /metadata/dc/rights |
| publication_date | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| title | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | /metadata/dc/title |