Data · study · 2026
Ultra-sensitive profiling of CRISPR-Cas off-target effects with Tracking-seq2
Listed in NCBI GEO
Accurate detection of off-target activity in patient-derived cells is critical for ensuring the safety of gene therapeutics.
Description
Here, we present Tracking-seq2—the most sensitive, cell-based, and clinically applicable off-target detection technology to date, capable of profiling diverse genome editors. Crucially, we reveal that genomic variations drive distinct off-target heterogeneity across different cells, highlighting the necessity for personalized safety assessment in clinical genome editing therapies
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE307nnn/GSE307225 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307225 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1314793 ncbi.nlm.nih.gov/bioproject/PRJNA1314793 ↗
project · from NCBI GEO
- PubMed 42716927 pubmed.ncbi.nlm.nih.gov/42716927 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Other
- From keywords
- Life Sciences
- Inferred from text
- Biochemistry and cell biology 70%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE307225 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3101 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (70%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |