Table · dataset · 2026
Table 1_Gray matter atrophy mediates the association between cerebral hypometabolism and cognitive impairment in Alzheimer’s disease.docx
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Objective<p>Alzheimer’s disease (AD) is characterized by amyloid deposition, brain hypometabolism, gray matter atrophy and cognitive decline, yet their causal interactions are poorly defined.
Description
This multimodal PET/MRI study explored regional gray matter volume (GMV) loss and glucose hypometabolism in AD patients, and clarified their correlations with distinct cognitive deficits alongside mediating pathways.</p>Methods<p>134 probable dementia patients were split into AD and non-AD dementia cohorts based on <sup>18</sup>F-AV45 PET amyloid-β (Aβ) load, all receiving structural MRI, <sup>18</sup>F-FDG and <sup>18</sup>F-AV45 PET scans.
We compared intergroup GMV and metabolic discrepancies, analyzed imaging-cognition correlations adjusted for clinical and demographic confounders, and implemented mediation models to test whether GMV bridges cerebral metabolism and cognition.</p>Results<p>AD patients exhibited prominent regional GMV shrinkage and FDG hypometabolism in vulnerable brain regions relative to non-AD dementia subjects. Covariate-adjusted analyses linked both imaging biomarkers to domain-specific cognitive performance.
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Primary mediation analyses showed that regional GMV significantly mediated the associations between FDG metabolism and visuospatial, executive, and language function, accounting for 40.36, 35.60, and 49.99% of the total effects, respectively. Reverse mediation models identified only a weak indirect effect of right superior temporal gyrus metabolism on the association between right inferior parietal lobule GMV and visuospatial ability, accounting for 13.26% of the total effect.
Moreover, after multiple-imputation sensitivity analyses, most indirect effects became unstable or nonsignificant, suggesting that the FDG metabolism–cognition association is predominantly direct, with limited evidence for GMV mediation.</p>Conclusion<p>Integrated PET/MRI revealed AD-related patterns of regional atrophy and hypometabolism. Overall, the association between cerebral metabolic dysfunction and cognitive impairment appeared to be predominantly direct, with limited evidence supporting a mediating role of regional GMV.</p>
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Where it is published
- DOI doi.org/10.3389/fneur.2026.1919778.s001 ↗
DOI / persistent id · from figshare com
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from figshare com
Topics
- From keywords
- Astronomy & Astrophysics · Chemistry · Computer Science & AI · Earth & Environmental Science · Economics & Finance · Engineering · Humanities · Life Sciences · Medicine & Health · Neurology and neuromuscular diseases · Ocean & Atmospheric Science · Social Science
- Inferred from text
- Disease 75% · Imaging 75% · Magnetic resonance imaging 65% · Tabular 65%
Provenance · 1 source records, 21 field assertions
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| figshare | oai:figshare.com:article/33794215 | 11 d ago | JSON v1 |
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